Minnesota Twins closer Jhoan Duran secured his 14th save of the season in a 4-2 win over the Chicago Cubs on Wednesday. Duran pitched a 1-2-3 ninth inning and needed a mere eight pitches to put the Cubs away. That makes five straight scoreless appearances for Duran, whose ERA is down to a microscopic 1.52 in 41 1/3 innings. The 27-year-old has also blown just two saves while posting 45:16 K:BB and a 1.09 WHIP.

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Kansas City Royals closer Carlos Estevez finished off a 4-3 win against the Pittsburgh Pirates on Wednesday to pick up his 25th save. The right-hander worked around a one-out single by Adam Frazier to throw a scoreless ninth inning with one strikeout on 16 pitches (11 strikes). The 32-year-old remains well on his way to his second 30-save season, and he's easily on pace to eclipse the career-high 31 he totaled in 2023. Estevez also has a sparkling 2.03 ERA and a 1.05 WHIP over 40 innings, though he hasn't been a great source of strikeouts (33).

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Kansas City Royals catcher Salvador Perez drilled a pair of key home runs to help the club escape with a 4-3 win over the Pittsburgh Pirates on Wednesday. Perez smashed a 444-foot solo blast off left-hander Bailey Falter to give the Royals a 1-0 lead in the bottom of the second inning. Later, with the game tied 3-3 in the eighth, Perez completed the scoring for the night with a 426-foot shot against righty Isaac Mattson. He also singled to finish 3-for-4 and continue a tremendous start to July. Perez has gone 13-for-35 with four homers and 11 RBI in nine games this month. The 35-year-old has also increased his OPS by over 100 points since the beginning of June. After a terrible start to the season, he's slashing .245/.285/.427 with 13 HRs, 54 RBI, and 24 runs in 370 plate appearances. Among catchers, only Seattle Mariners MVP candidate Cal Raleigh has driven in more runs than Perez.

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New York Yankees closer Devin Williams collected his 13th save of 2025 in a 9-6 win over the Seattle Mariners on Wednesday. Williams entered in the top of the ninth inning and made quick work of the Mariners, going 1-2-3 on 12 pitches (eight strikes). He struck out both Dominic Canzone and Cole Young swinging. The 30-year-old's ERA has fallen to 4.86 (2.51 FIP) with 43:14 K:BB and a 1.17 WHIP in 33 1/3 innings. Williams has endured his share of struggles this year, but his only blown save came way back on April 19.

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Milwaukee Brewers closer Trevor Megill (2-2) earned his second victory of the season in a 3-2 defeat of the Los Angeles Dodgers on Wednesday. The flamethrowing right-hander entered a 2-2 game in the top of the 10th inning and dominated, striking out Freddie Freeman, Andy Pages, and Tommy Edman in order on 13 pitches (11 strikes). The Brewers won in the bottom of the 10th on a Jackson Chourio walk-off single. Megill, meanwhile, dropped his ERA to 2.41 with 21 saves, a 1.16 WHIP, and 43 strikeouts against 15 walks in 33 2/3 innings. He earned his first All-Star selection on Wednesday.

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Los Angeles Dodgers right-hander Tyler Glasnow held his own Wednesday in his first major league start since April 27. After missing over two months with shoulder inflammation, Glasnow limited the Milwaukee Brewers to one unearned run on two hits with five strikeouts and three walks over five innings. The 31-year-old threw 85 pitches (53 strikes) and recorded a max velocity of 99.5 mph on the radar gun. The Dodgers fell 3-2 despite Glasnow's efforts, but he did not factor into the decision. Glasnow will head into the second half of the season with a 3.52 ERA and 28:14 K:BB in 23 innings. He could be a major asset for the Dodgers and fantasy managers down the stretch, though staying healthy has typically been a challenge for him.

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The New York Yankees have designated infielder DJ LeMahieu for assignment and recalled rookie infielder Jorbit Vivas from Triple-A Scranton/Wilkes-Barre. The writing was on the wall for LeMahieu when the Yankees demoted him to a bench role on Tuesday to shift Jazz Chisholm Jr. from third base to second. Although LeMahieu has past third base experience, the 36-year-old is no longer physically capable of handling the position. With both his defensive and offensive skills eroding, the Yankees no longer deemed LeMahieu worthy of a roster spot. The two-time batting champion and former AL MVP candidate hit .266/.338/.336 with two home runs and 12 RBI in 142 plate appearances this year before the Yankees cut him from their roster. New York will pay approximately $22 million to get rid of LeMahieu, who will head to the open market in the coming days. LeMahieu may find another team in free agency, but his days of fantasy relevance are over.

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Washington Nationals starter Trevor Williams (elbow) has a partial tear in his right ulnar collateral ligament and will require surgery, according to Spencer Nusbaum of the Washington Post. Williams expects to have internal brace surgery, not a full Tommy John procedure, but he'll still miss the rest of the season and perhaps some of the 2026 campaign. This news ends a brutal season for Williams, who re-signed with the Nationals on a two-year, $14 million contract last winter. The 33-year-old struggled to a 3-10 record with a 6.21 ERA, a 1.54 WHIP, 65 strikeouts, and 21 walks in 82 2/3 innings.

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Los Angeles Dodgers reliever Michael Kopech (knee) has undergone surgery on a torn meniscus in his right knee, Bill Plunkett of the Orange County Register reports. The Dodgers moved Kopech from the 15-day injured list to the 60-day IL as a result. Kopech's IL stint dates back to June 28, meaning he won't be eligible to return until the end of August. The Dodgers do expect Kopech back before the year is out, but this will largely go down as an injury-ruined regular season for him. The 29-year-old didn't debut until June 8 after dealing with an impingement in his right shoulder. He pitched well in eight appearances between IL stints, throwing seven scoreless, three-hit innings with eight strikeouts, four walks, and five holds.

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Houston Astros outfielder Jake Meyers (calf) was in the team's lineup on Wednesday, but he exited before their game against the Cleveland Guardians began. Meyers left the field during pregame warmups with help from an athletic trainer. The 29-year-old had been set to return from the right-calf injury that he suffered in a win over the Los Angeles Dodgers on Sunday. Instead, the Astros shifted Mauricio Dubon to center field and subbed in the aptly named Zack Short to handle shortstop. The club should have more on Meyers' status after the game.

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Minnesota Twins outfielder Byron Buxton departed the team's game against the Chicago Cubs on Wednesday after suffering a left-hand contusion on a hit by pitch. X-rays came back negative for a fracture, and Buxton is considered day-to-day, Dan Hayes of The Athletic reports. Buxton led off the bottom of the first inning against Cubs starter Cade Horton with the HBP, but he stayed in until the Twins pinch-hit Brooks Lee for him in the second. The two-time All-Star stole a base and scored a run before exiting. Buxton has an extensive injury history that has prevented him from reaching his full potential, though it appears he dodged disaster in this case. The 31-year-old has stayed healthy for most of this season and posted fantastic production. He's hitting .270/.338/.544 with 20 homers, 53 RBI, 60 runs, and 17 steals across 320 plate appearances.

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Miami Marlins outfielder Kyle Stowers is absent from the starting lineup ahead of Wednesday's game against the Cincinnati Reds. Stowers will head to the bench for the first time since June 29. The left-handed slugger has been solid recently with at least one hit in 13 of his last 15 games. In his absence, Heriberto Hernandez will take over in left field and bat third versus left-hander Andrew Abbott. Hernandez doesn't offer enough upside to warrant streaming against a tough southpaw in Abbott. Fantasy managers should adjust their lineups ahead of first pitch.

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Atlanta Braves outfielder Ronald Acuna Jr. (back) is returning to the starting lineup ahead of Wednesday's game against the Athletics. Acuna was scratched from Tuesday's contest due to lower back tightness. Luckily, Acuna will only miss one game and is back in the leadoff spot and playing right field versus right-hander Mitch Spence on Wednesday. Acuna has been in a little slump at the plate, but he remains a must-start in all fantasy formats. It's unclear if this back issue is going to impact him performing in the upcoming Home Run Derby. Regardless, fantasy managers can get Acuna back in their lineups on Wednesday.

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Philadelphia Phillies outfielder Max Kepler (shin) was forced to make an early exit from Wednesday's game against the San Francisco Giants. Kepler seemed fine until being pulled out for Johan Rojas in the eighth inning. It has been revealed that Kepler is dealing with a right shin contusion, so fantasy managers should consider him as day-to-day. He finished this game 1-for-3 with a single and an RBI. The Phillies are off on Thursday, so possibly Kepler is back in the mix on Friday. If not, Rojas could see more action in the outfield over the weekend.

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Athletics shortstop Jacob Wilson (hand) will take a seat ahead of Wednesday's game against the Atlanta Braves. This doesn't come as a shock after Wilson was hit in the left hand by a pitch during Tuesday's game. It doesn't sound like Wilson suffered any serious injuries, but he'll likely undergo more testing. For now, fantasy managers should consider Wilson as day-to-day. Max Muncy will take over at shortstop and bat sixth versus left-hander Bryce Elder on Wednesday. Fantasy managers should adjust their lineups ahead of first pitch.

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Miami Marlins starting pitcher Edward Cabrera is expected to have a fairly large trade market this summer. The Chicago Cubs, New York Mets, and reportedly other organizations are looking at acquiring Cabrera ahead of the trade deadline. The Marlins should be able to get a good return on Cabrera, assuming they're willing to move him. He's under contract through 2026 with an affordable deal. This season, Cabrera holds a 3.33 ERA, 1.22 WHIP, and 80/33 K/BB ratio across 15 starts. The Marlins don't need to trade Cabrera with him still under contract, but might cash-in on his value while it's high. This is a situation to monitor over the next few weeks.

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Houston Astros outfielder Jake Meyers (calf) is starting in center field and will bat out of the two-hole for Wednesday's game against the visiting Cleveland Guardians and right-hander Slade Cecconi. Meyers suffered a right-calf injury in Sunday's game against the Dodgers in Los Angeles and then missed the last two games as a result. The 29-year-old is feeling better on Wednesday, though, and will return to action against a pitcher that he's never faced in his career. Although Meyers has only three long balls on the season in his 88 games played, he's having a breakout season otherwise for the Astros by slashing .308/.369/.405 with 21 RBI, 47 runs scored and a career-high 14 stolen bases in 322 plate appearances. He's gone 7-for-21 (.333) with two doubles, a triple, an RBI and eight runs scored in the first six games of July.

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The Chicago Cubs placed right-handed reliever Porter Hodge (shoulder) on the 15-day injured list on Wednesday with a shoulder injury, according to manager Craig Counsell. Pitcher Ethan Roberts will be recalled from the minors in a corresponding move. "I don't think it's anything major, but we're dealing with a little shoulder stuff -- we got to get it out of there and have him clear-headed," Counsell says. The 24-year-old missed time earlier this year with hip and oblique injuries, but now he's back on the shelf and may not be ready to return until August. In just one-third of an inning of work in Tuesday's loss to the Minnesota Twins, Hodge surrendered six earned runs on five hits (three homers) while walking one and striking out one. He's had a roughs second year in the majors between his injuries and a bloated 6.85 ERA.

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St. Louis Cardinals third baseman Nolan Arenado (shoulder) is back at third base and will hit fifth on Wednesday against the visiting Washington Nationals and left-hander MacKenzie Gore. Arenado will return to the hot corner after missing the last three games with a right-shoulder impingement. The 34-year-old has been beat up of late, as he also missed a few games last week with a minor finger injury. The matchup isn't a great one for DFS purposes, although Arenado has hit .444 with a home run and five RBI in his career against Gore in nine at-bats. Arenado has been cold offensively of late, going 6-for-28 (.214) with two doubles, two RBI, a run scored, one walk and two strikeouts in eight games played since June 24. He does have 41 RBI in 81 games for St. Louis this year, but Arenado is hitting a modest .248 (76-for-307), and his power (10 homers) continues to dwindle.

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