Kansas City Chiefs running back Isiah Pacheco (knee) has officially been ruled out for his team's Week 11 matchup against the Denver Broncos, per Ian Rapoport of NFL Network. This will mark Pacheco's second straight missed game after he suffered an MCL sprain in Week 8. Without him, Kansas City will likely turn to veteran running back Kareem Hunt to handle the majority of their backfield work. Hunt recorded 11 carries for 49 yards and a touchdown in Week 9 against the Buffalo Bills with Pacheco sidelined. Rookie running back Brashard Smith could mix in as well, but Smith earned just four touches against Buffalo. Hunt profiles as a borderline RB2/high-end flex option for fantasy managers in Week 11. Pacheco should have a chance to return to the field in Week 12 when the Chiefs host the Indianapolis Colts.

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Chicago Bears wide receiver DJ Moore (shoulder) will not carry an injury designation and will play in his team's Week 11 matchup against the Minnesota Vikings, according to Sean Hammond of the Chicago Tribune. Moore has been limited in practice this week due to the injury, but it appears it will not keep him from suiting up in a crucial divisional contest. Moore has not missed a game since the 2020 season. The 30-year-old has hauled in 30 catches for 403 yards and a touchdown on 48 targets across nine games this season. However, he's coming off a four-target, zero-catch game in Week 10 against the New York Giants. It's possible that the shoulder injury could keep Moore from playing his usual allotment of snaps and could open up some additional opportunities for Bears rookie wideout Luther Burden III. Moore profiles as a low-end WR3/high-end WR4 for fantasy managers in Week 11 against Minnesota.

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Minnesota Vikings quarterback J.J. McCarthy (right hand) is off the injury report and "good to go" for his team's Week 11 matchup against the Chicago Bears, per Tom Pelissero of NFL Network. McCarthy has been battling swelling in his throwing hand after hitting it on a helmet during Minnesota's Week 10 loss to the Baltimore Ravens, but it appears it won't prevent him from suiting up against Chicago. Across four starts this season, the 22-year-old has completed 53.7% of his pass attempts for 692 yards, five touchdowns, and six interceptions. He's been more productive with his legs, rushing for 110 yards and two touchdowns on 21 attempts. McCarthy profiles as a solid fantasy starter in two-quarterback formats, but should likely be avoided in single-QB leagues against Chicago in Week 11.

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The Cincinnati Bengals will be without defensive ends Trey Hendrickson (hip, pelvis) and Shemar Stewart (knee) in Week 11 against the Pittsburgh Steelers, per ESPN's Ben Baby. Hendrickson last played in Week 7, so this will mark his fourth straight game on the shelf. The 30-year-old recorded four sacks and eight QB hits before getting injured and might be the only true impact player on the struggling Cincinnati defense. Stewart has had an injury-marred rookie campaign, as he's appeared in just five games in 2025. The 22-year-old is still looking for his first NFL sack. Both Hendrickson and Stewart are considered week-to-week, so they could be back for Cincinnati's Week 12 matchup against the New England Patriots. Without them in the lineup, the Bengals will rely on Joseph Ossai and Myles Murphy to lead their pass rush against Pittsburgh.

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New York Giants rookie quarterback Jaxson Dart (concussion) has officially been ruled out for his team's Week 11 matchup against the Green Bay Packers, per Tom Pelissero of NFL Network. Dart suffered a concussion that forced him to exit early from his team's Week 10 loss to the Chicago Bears and has spent this week in the league's concussion protocol. However, Giants interim head coach Mike Kafka recently said that Dart is progressing well, so he may be on track to return in Week 12 against the Detroit Lions. With Dart sidelined against Green Bay, quarterback Jameis Winston will make his first start of the season for New York. In 12 games (seven starts) for the Cleveland Browns in 2024, Winston threw for 2,121 yards, 13 touchdowns, and 12 interceptions. The veteran gunslinger profiles as a low-end fantasy QB2 in Week 11 against the Packers.

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Philadelphia running back Tank Bigsby took his first offensive snaps with the Eagles in Week 7 and followed that up by turning nine carries into 104 yards in a Week 8 win over the Giants that saw starter Saquon Barkley exit early with a groin injury. With the Eagles on a Week 9 bye, Barkley's health remained in question heading into Week 10, making Bigsby a popular waiver add over those two weeks. In Week 10's win over the Packers, Barkley outsnapped Bigsby 44 to eight and saw 25 total opportunities to Bigsby's 3, proving once again that when healthy, the Eagles' backfield belongs to Barkley. Bigsby is still worthy of a roster spot as the apparent next man up behind Barkley, but heading into a Week 11 matchup with the Lions, he has no standalone value.

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New York Giants wide receiver Darius Slayton (hamstring) is one of three Giants players to have already been ruled out for Sunday's Week 11 matchup with the Packers, along with quarterback Jaxson Dart (concussion). With Mike Kafka serving as interim head coach following the Monday firing of Brian Daboll, the team has already announced plans to start journeyman quarterback Jameis Winston, but who he will be throwing to is now another question entirely. Receiver Wan'Dale Robinson and tight end Theo Johnson suddenly become very interesting plays for fantasy managers willing to roll the dice and shoot for upside. Even against a Packers' pass defense that has been suffocating at times, Winston's propensity to hyper-target his top pass catchers and willingness to throw into windows that most quarterbacks would not, is a recipe for fantasy fireworks.

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Los Angeles Rams wide receiver Davante Adams (oblique) will be questionable for Week 11's divisional clash with the Seahawks. Head coach Sean McVay told reporters on Friday that his veteran star has progressed well throughout the week, and the team expects to have him available on Sunday. Both the Rams and Seahawks come into Sunday's game with matching 7-2 records, tied not only at the top of the NFC West but also in a three-way tie with the Eagles for the best record in the conference. Adams has been a major piece of a Rams' offense that sees quarterback Matthew Stafford firmly entrenched in MVP conversations. He has become the team's primary weapon near the goal line, bringing in six touchdown grabs over his last three games. Should he miss Sunday's game, running back Kyren Williams becomes even more likely to keep his own touchdown streak alive, having also found paydirt three times in his last two outings.

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Atlanta Falcons wide receiver Drake London (illness/back) is questionable for Sunday's divisional matchup with the Panthers after missing Wednesday's practice with an illness and then returning as a limited participant on Thursday with an additional back ailment. London has been on a tear of late, topping 100 yards in each of his last two games while finding the endzone four times over that span. Should he miss Sunday's game, receiver Darnell Mooney and tight end Kyle Pitts are the most likely candidates to see an uptick in targets. However, neither has demonstrated a strong connection with second-year quarterback Michael Penix Jr. to this point. The Falcons play in Sunday's early window of games, giving fantasy managers a chance to at least monitor London's gameday status and pivot if necessary.

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Los Angeles Chargers wide receiver Ladd McConkey (ankle) was a full participant at Friday's practice and carries no injury designation into the team's Week 11 matchup with the Jaguars. McConkey is coming off one of his best games of the season after converting six targets into four catches for 107 yards and a touchdown in a Week 10 win over the Steelers. While he got off to a slow start, and the Chargers' offense has seemed to lean on a different pass catcher every few weeks, McConkey has played his way back into must-start status over the past month-plus. He has finished as the WR5 or better in half-PPR formats in three of the last five weeks, while boasting five touchdown grabs in his last six games. The Jaguars have been a middle-of-the-pack defense to target for fantasy wide receivers, and McConkey is RotoBaller's WR13 for the week.

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New York Jets head coach Aaron Glenn said on Friday that he expects wide receiver Garrett Wilson (knee) to play again this year, but Glenn also added that it's up to the doctors, according to Antwan V. Staley of the New York Daily News. Wilson missed several games with a knee injury before returning in the Week 10 win over the Cleveland Browns, only to aggravate his knee. The Jets placed the 25-year-old on Injured Reserve this week, so he'll be forced to miss at least the next three games following the team's Thursday night loss to the New England Patriots. He won't be eligible to play before Sunday, Dec. 14, against the Jaguars. With Wilson out for the foreseeable future, John Metchie III and Adonai Mitchell figure to be featured as the team's top pass-catchers in what has been the worst passing offense in football this year. Fantasy managers stashing Wilson need to know that there's a chance he won't contribute again in 2025.

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Baltimore Ravens head coach John Harbaugh said on Friday that quarterback Lamar Jackson (knee) is a full-go for Sunday's contest against the division-rival Cleveland Browns in Week 11. There was some concern over Jackson's status after he did not practice on Wednesday, but he was only dealing with a sore knee and returned to a full practice the following day. The 28-year-old two-time MVP missed some time earlier this year with a hamstring strain, but this weekend will be his third game back in action. The four-time Pro Bowler currently leads the NFL in touchdown percentage (10.2), adjusted yards gained per pass attempt (10.23), and passer rating (127.1) while throwing for 1,249 yards, 15 touchdowns, and only one interception in six starts. Despite facing a decent Browns defense, Jackson is a no-doubt, must-start at the QB position in fantasy.

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New York Giants head coach Mike Kafka said on Friday that he thinks rookie quarterback Jaxson Dart (concussion) is "on track" with where he's supposed to be in the league's concussion protocol, according to Jordan Raanan of ESPN. Dart was seen warming up with the team on the field in practice on Friday, which is a good sign that he might be cleared to play in Week 12 versus the Pittsburgh Steelers. However, he will not be available to play this Sunday against the Green Bay Packers. Veteran QB Jameis Winston, not Russell Wilson, will make the start in Week 11, and he's expected to be without receiver Darius Slayton (hamstring). Fantasy managers will be hoping that Dart will end up missing just one game. The rookie first-rounder has immediately become fantasy relevant as a QB1 because of his dual-threat abilities at the position.

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The Los Angeles Chargers have listed wide receiver Quentin Johnston (shin) as questionable to play in Week 11 against the hosting Jacksonville Jaguars on Sunday. Johnston has been limited in practice this week after apparently picking up a shin injury in Sunday night's win over the Pittsburgh Steelers. We'd be surprised if the 24-year-old former first-rounder is unable to play this weekend, but fantasy managers will want to check back on Sunday morning to confirm it. The good news is the Chargers play in the early window at Jacksonville in Week 11. Although most of Johnston's damage in 2025 came early on, he did have double-digit targets in Week 10 for the second time this year, and he's scored six touchdowns already. If he's active, Johnston still has plenty of boom potential for fantasy managers as a WR3/flex.

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Carolina Panthers running back Rico Dowdle (quadriceps) was removed from Friday's final injury report and will play on Sunday against the division-rival Atlanta Falcons in Week 11, according to Darin Gantt of Panthers.com. Dowdle missed practice on Wednesday for the second straight week with a minor quad injury, but he returned to practice on Thursday and is now in the clear to play this weekend as Carolina's lead back. The 27-year-old has been one of the NFL's most dominant RBs in 2025, vaulting him into a top-five weekly play at the position in fantasy football. He played through his quad issue in last week's loss to the New Orleans Saints and had 21 touches for 64 yards. Dowdle is averaging a career-best 5.3 yards per carry in his first year with the Panthers for 788 rushing yards and five touchdowns on 149 carries. He has added 18 catches for 142 yards and another score. Keep him locked into your starting lineup.

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Tampa Bay Buccaneers head coach Todd Bowles told reporters on Friday that wide receiver Chris Godwin (leg) will be out on Sunday against the Buffalo Bills in Week 11, according to NFL Network's Ian Rapoport. Godwin has not played since suffering a fibula injury in Week 5, but the good news is that the 29-year-old was able to make progress this week and put in three limited practices. Godwin didn't make his season debut until Week 4 after dislocating his ankle in Week 7 of last year, and he played in just two games before getting hurt again. Although Mike Evans (collarbone) is potentially out for the regular season, the Bucs aren't going to rush Godwin back, and he might not return until early December. Even if he makes more progress in practice next week, fantasy managers shouldn't consider it a lock that Godwin will play in Week 12 against the Los Angeles Rams on Sunday night. Rookies Emeka Egbuka and Tez Johnson should continue to see most of the targets with Godwin sidelined.

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The Chicago Bears opened the 21-day practice window for cornerback Jaylon Johnson (groin) on Friday, according to Adam Schefter of ESPN. Johnson is making progress after undergoing core-muscle surgery earlier this season, and the Bears now have 21 days to officially activate the 26-year-old defensive back from Injured Reserve. Johnson was injured in Week 2 against the Detroit Lions, the only game he's appeared in this year. He will not be ready to return for this weekend's game against the division-rival Minnesota Vikings, but depending on how he progresses next week, there's a possibility he'll be back in the fold in Week 12 against the Pittsburgh Steelers. Johnson's return in the second half will be great news for a Bears team that leads the league in turnover differential by a wide margin.

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Baltimore Ravens quarterback Lamar Jackson (knee) was seen practicing again on Friday, according to Jonas Shaffer of The Baltimore Sun. Fantasy managers may have panicked a little bit earlier this week when it was announced that Jackson didn't practice on Wednesday due to a knee injury. However, the two-time MVP returned to a full practice on Thursday, and he should be just fine to suit up for a divisional meeting with the Cleveland Browns on Sunday. In two games since returning from a hamstring injury that knocked Jackson out for several games, he's gone 35-for-52 passing for 380 yards, five touchdowns, and no interceptions while running for 50 yards on 14 attempts. Even though Jackson might still be getting his legs back under him, he's a must-start this weekend against the Browns. Back in Week 2, Jackson threw for 225 yards and four touchdowns against them in a 41-17 victory.

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Tampa Bay Buccaneers head coach Todd Bowles told reporters on Friday that running back Bucky Irving (foot, shoulder) will be out this Sunday against the Buffalo Bills in Week 11, according to Ian Rapoport of NFL Network. It's a disappointment for Irving's fantasy managers, but the silver lining is that he was able to turn a corner this week and take part in three limited practices. The 23-year-old hasn't played since Week 4 due to a subluxation of his shoulder and a foot sprain, but if he can upgrade to a full practice at some point next week, he could be back for a Sunday Night Showdown in Week 12 against the Los Angeles Rams. With Irving missing another week, both Rachaad White and Sean Tucker will have elevated roles in Tampa's backfield. White is on the RB2/3 borderline, while Tucker is more of an RB3/flex in fantasy football.

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New York Giants interim head coach Mike Kafka said that wide receiver Darius Slayton (hamstring) will not practice on Friday and is not expected to suit up on Sunday against the visiting Green Bay Packers in Week 11, according to Pat Leonard of the New York Daily News. Slayton picked up a hamstring injury in the Week 10 loss to the Chicago Bears and was unable to practice all week, so fantasy managers need to put him on their bench for the weekend. The G-Men will also be without rookie quarterback Jaxson Dart after he suffered a concussion last weekend. So the Giants' offense will be run by veteran gunslinger Jameis Winston, making Green Bay's defensive unit a must-start in fantasy leagues. Wan'Dale Robinson should see heavy targets in the passing game, with Jalin Hyatt, Isaiah Hodgins, and Gunner Olszewski also seeing expanded roles. Tight end Theo Johnson will likely be Winston's No. 2 target.

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